|
KMID : 0379520130290010007
|
|
한국독성학회지
2013 Volume.29 No. 1 p.7 ~ p.14
|
|
|
Betaine Alleviates Hypertriglycemia and Tau Hyperphosphorylation in db/db Mice
|
|
Jung Ga-young
Won Sae-Bom
Kim Ju-Hae
Jeon Sook-Young
Han An-Na
Kwon Young-Hye
|
|
|
Abstract
|
|
|
|
Betaine supplementation has been shown to alleviate altered glucose and lipid metabolism in mice fed a high-fat diet or a high-sucrose diet. We investigated the beneficial effects of betaine in diabetic db/db mice. Alleviation of endoplasmic reticulum (ER) and oxidative stress was also examined in the livers and brains of db/db mice fed a betaine-supplemented diet. Male C57BL/KsJ-db/db mice were fed with or without 1% betaine for 5 wk (referred to as the db/db-betaine group and the db/db group, respectively). Lean non-diabetic db/db+ mice were used as the control group. Betaine supplementation significantly alleviated hyperinsulinemia in db/db mice. Betaine reduced hepatic expression of peroxisome proliferator-activated receptor gamma coactivator 1 alpha, a major transcription factor involved in gluconeogenesis. Lower serum triglyceride concentrations were also observed in the db/db-betaine group compared to the db/db group. Betaine supplementation induced hepatic peroxisome proliferator-activated receptor alpha and carnitine palmitoyltransferase 1a mRNA levels, and reduced acetyl-CoA carboxylase activity. Mice fed a betaine-supplemented diet had increased total glutathione concentrations and catalase activity, and reduced lipid peroxidation levels in the liver. Furthermore, betaine also reduced ER stress in liver and brain. c-Jun N-terminal kinase activity and tau hyperphosphorylation levels were lower in db/db mice fed a betaine-supplemented diet, compared to db/db mice. Our findings suggest that betaine improves hyperlipidemia and tau hyperphosphorylation in db/db mice with insulin resistance by alleviating ER and oxidative stress.
|
|
|
KEYWORD
|
|
|
Betaine, db/db mice, ER stress, Insulin resistance, Oxidative stress, Tau phosphorylation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|